Exhibit 21
Genworth Financial, Inc.’s subsidiaries as of December 31, 2025 are listed below. Except where noted below, Genworth Financial, Inc. owns, directly or indirectly, 100% of the outstanding shares or other equity interests of these companies (including, with respect to certain companies, shares in names of nominees and qualifying shares in names of directors).

Name |  | Domicile
Assigned Settlement, Inc. |  | Virginia
Capital Brokerage Corporation |  | Washington
CareScout, LLC |  | Delaware
CareScout Holdings, Inc. |  | Delaware
CareScout Insurance Company |  | Virginia
Enact Financial Assurance Corporation(1) |  | North Carolina
Enact Financial Services, Inc.(1) |  | Delaware
Enact Global Holdings Corporation(1) |  | North Carolina
Enact Holdings, Inc.(1) |  | Delaware
Enact Mortgage Holdings, LLC(1) |  | North Carolina
Enact Mortgage Insurance Corporation(1) |  | North Carolina
Enact Mortgage Insurance Corporation of North Carolina(1) |  | North Carolina
Enact Mortgage Services, LLC(1) |  | North Carolina
Enact Residential Insurance Corporation(1) |  | North Carolina
Enact Re Ltd.(1) |  | Bermuda
Genworth Annuity Service Corporation |  | Delaware
Genworth Financial Agency, Inc. |  | Virginia
Genworth Financial Asia Limited |  | Hong Kong
Genworth Financial India Private Limited |  | India
Genworth Financial International Holdings, LLC |  | Delaware
Genworth Financial Mauritius Holdings Limited(1) |  | Mauritius
Genworth Holdings, Inc. |  | Delaware
Genworth Life and Annuity Insurance Company |  | Virginia
Genworth Life Insurance Company (dba GLIC in New York) |  | Delaware
Genworth Life Insurance Company of New York |  | New York
Genworth North America Corporation |  | Washington
Genworth Seguros de Credito a la Vivienda, S.A. de C.V. |  | Mexico
Genworth Servicios, S. de R. L. de C. V. |  | Mexico
GFCM LLC |  | Delaware
GLIC Real Estate Holding, LLC |  | Delaware
GLICNY Real Estate Holding, LLC |  | Delaware
GNWLAAC Real Estate Holding, LLC |  | Delaware
HGI Annuity Service Corporation |  | Delaware
Jamestown Assignment Company, Inc. |  | Virginia
Mayflower Assignment Corporation |  | New York
Monument Lane PCC, Inc.(1) |  | Washington, D.C.
Monument Lane IC 1, Inc.(1) |  | Washington, D.C.
Monument Lane IC 2, Inc.(1) |  | Washington, D.C.
Newco Properties, Inc. |  | Virginia
River Lake Insurance Company VI |  | Delaware
River Lake Insurance Company X |  | Vermont
Seniorly, Inc. |  | Delaware
Sponsored Captive Re, Inc.(1) |  | North Carolina
United Pacific Structured Settlement Company |  | Florida

(1) | Genworth Financial, Inc. beneficially owns approximately 81% of the shares.