Exhibit 21

Genworth Financial, Inc.’s subsidiaries as of December 31, 2021 are listed below. Except where noted below, Genworth Financial, Inc. owns, directly or indirectly, 100% of the outstanding shares or other equity interests of these companies (including, with respect to certain companies, shares in names of nominees and qualifying shares in names of directors).



Assigned Settlement, Inc.    Virginia
Capital Brokerage Corporation    Washington
CareScout, LLC    Delaware
Enact Financial Assurance Corporation(1)    North Carolina
Enact Holdings, Inc.(1)    Delaware
Enact Mortgage Holdings, LLC(1)    North Carolina
Enact Mortgage Insurance Corporation(1)    North Carolina
Enact Mortgage Insurance Corporation of North Carolina(1)    North Carolina
Enact Mortgage Reinsurance Corporation(1)    North Carolina
Enact Mortgage Services, LLC(1)    North Carolina
Genworth Annuity Service Corporation    Delaware
Genworth Financial Agency, Inc.    Virginia
Genworth Financial Asia Limited    Hong Kong
Genworth Financial India Private Limited    India
Genworth Financial International Holdings, LLC    Delaware
Genworth Financial Mauritius Holdings Limited(1)    Mauritius
Genworth Financial Services, Inc.(1)    Delaware
Genworth Holdings, Inc.    Delaware
Genworth Insurance Company    North Carolina
Genworth Life and Annuity Insurance Company    Virginia
Genworth Life Insurance Company (dba GLIC in New York)    Delaware
Genworth Life Insurance Company of New York    New York
Genworth North America Corporation    Washington
Genworth Seguros de Credito a la Vivienda, S.A. de C.V.    Mexico
Genworth Servicios, S. de R. L. de C. V.    Mexico
Genworth (Shanghai) Health Consulting Services Company Limited    China
GFCM LLC    Delaware
GLIC Real Estate Holding, LLC    Delaware
GLICNY Real Estate Holding, LLC    Delaware
GNWLAAC Real Estate Holding, LLC    Delaware
HGI Annuity Service Corporation    Delaware
Jamestown Life Insurance Company    Virginia
Mayflower Assignment Corporation    New York
Monument Lane PCC, Inc.(1)    Washington, D.C.
Monument Lane IC 1, Inc.(1)    Washington, D.C.
Monument Lane IC 2, Inc.(1)    Washington, D.C.
Newco Properties, Inc.    Virginia
River Lake Insurance Company VI    Delaware
River Lake Insurance Company VII    Vermont
River Lake Insurance Company VIII    Vermont
River Lake Insurance Company X    Vermont
Sponsored Captive Re, Inc.(1)    North Carolina
United Pacific Structured Settlement Company    Florida



Genworth Financial, Inc. beneficially owns 81.6% of the shares.